USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: PRDX3_HUMAN USC-OGP 2-DE database:  PRDX3_HUMAN PRDX3_HUMAN General information about the entry View entry in simple text format Entry name PRDX3_HUMAN Primary accession number P30048 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Thioredoxin-dependent peroxide reductase, mitochondrial; EC=1.11.1.15; AltName: Full=Antioxidant protein 1; Short=AOP-1; AltName: Full=HBC189; AltName: Full=Peroxiredoxin III; Short=Prx-III; AltName: Full=Peroxiredoxin-3; AltName: Full=Protein MER5 homolog; Flags: Precursor;. Gene name Name=PRDX3 Synonyms=AOP1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0546: pI=5.86; Mw=23451 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0822: pI=5.86; Mw=23512 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1024: pI=5.75; Mw=23611 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1293: pI=6.12; Mw=24496 Cross-references UniProtKB/Swiss-Prot P30048; PRDX3_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PRDX3_HUMAN Primary accession number P30048 Secondary accession number(s) B2R7Z0 D3DRC9 E9PH29 P35690 Q0D2H1 Q13776 Q5T5V2 Q96HK4 Sequence was last modified on  November 1, 1997 (version 3) Annotations were last modified on  March 15, 2017 (version 201) Name and origin of the protein Description RecName: Full=Thioredoxin-dependent peroxide reductase, mitochondrial; EC=1.11.1.15; AltName: Full=Antioxidant protein 1; Short=AOP-1; AltName: Full=HBC189; AltName: Full=Peroxiredoxin III; Short=Prx-III; AltName: Full=Peroxiredoxin-3; AltName: Full=Protein MER5 homolog; Flags: Precursor; Gene name Name=PRDX3 Synonyms=AOP1 Encoded on Name=PRDX3; Synonyms=AOP1 Keywords 3D-structure; Acetylation; Alternative splicing; Antioxidant; Complete proteome; Direct protein sequencing; Disulfide bond; Mitochondrion; Oxidoreductase; Peroxidase; Phosphoprotein; Polymorphism; Redox-active center; Reference proteome; Transit peptide. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D49396; BAA08389.1; -; mRNA EMBL AK313169; BAG35987.1; -; mRNA EMBL CR450344; CAG29340.1; -; mRNA EMBL BT020007; AAV38810.1; -; mRNA EMBL DQ298752; ABB84468.1; -; Genomic_DNA EMBL AL355861; CAI15802.1; -; Genomic_DNA EMBL CH471066; EAW49399.1; -; Genomic_DNA EMBL BC002685; AAH02685.1; -; mRNA EMBL BC007062; AAH07062.1; -; mRNA EMBL BC008435; AAH08435.1; -; mRNA EMBL BC009601; AAH09601.1; -; mRNA EMBL BC021691; AAH21691.1; -; mRNA EMBL BC022373; AAH22373.1; -; mRNA EMBL BC059169; AAH59169.1; -; mRNA EMBL BC111397; AAI11398.1; -; mRNA CCDS CCDS7611.1; -. [P30048-1]; . RefSeq NP_001289201.1; NM_001302272.1; . RefSeq NP_006784.1; NM_006793.4. [P30048-1]; . UniGene Hs.523302; -; . PDB 5JCG; X-ray; 2.80 A; A/B/C/D/E/F/G/H/I=62-256 PDBsum 5JCG; -; . ProteinModelPortal P30048; -; . SMR P30048; -; . BioGrid 116136; 64; . DIP DIP-33600N; -; . IntAct P30048; 57; . MINT MINT-195453; -; . STRING 9606.ENSP00000298510; -; . PeroxiBase 4492; Hs2CysPrx03; . iPTMnet P30048; -; . PhosphoSitePlus P30048; -; . SwissPalm P30048; -; . DMDM 2507171; -; . OGP P30048; -; . SWISS-2DPAGE P30048; -; . UCD-2DPAGE P30048; -; . EPD P30048; -; . MaxQB P30048; -; . PaxDb P30048; -; . PeptideAtlas P30048; -; . PRIDE P30048; -; . TopDownProteomics P30048-1; -. [P30048-1]; . DNASU 10935; -; . Ensembl ENST00000298510; ENSP00000298510; ENSG00000165672. [P30048-1]; . GeneID 10935; -; . KEGG hsa:10935; -; . UCSC uc001lec.5; human. [P30048-1]; . CTD 10935; -; . DisGeNET 10935; -; . GeneCards PRDX3; -; . H-InvDB HIX0035477; -; . HGNC HGNC:9354; PRDX3; . HPA CAB008656; -; . HPA HPA041488; -; . MIM 604769; gene; . neXtProt NX_P30048; -; . OpenTargets ENSG00000165672; -; . PharmGKB PA33724; -; . eggNOG KOG0852; Eukaryota; . eggNOG COG0450; LUCA; . GeneTree ENSGT00390000004653; -; . HOVERGEN HBG000286; -; . InParanoid P30048; -; . KO K20011; -; . OMA TQHAPAF; -; . OrthoDB EOG091G0IE5; -; . PhylomeDB P30048; -; . TreeFam TF105181; -; . Reactome R-HSA-3299685; Detoxification of Reactive Oxygen Species; . ChiTaRS PRDX3; human; . GeneWiki PRDX3; -; . GenomeRNAi 10935; -; . PRO PR:P30048; -; . Proteomes UP000005640; Chromosome 10; . Bgee ENSG00000165672; -; . CleanEx HS_PRDX3; -; . Genevisible P30048; HS; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:ParkinsonsUK-UCL; . GO GO:0005769; C:early endosome; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005759; C:mitochondrial matrix; TAS:Reactome; . GO GO:0005739; C:mitochondrion; IDA:UniProtKB; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0008785; F:alkyl hydroperoxide reductase activity; NAS:UniProtKB; . GO GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IMP:UniProtKB; . GO GO:0019900; F:kinase binding; IPI:UniProtKB; . GO GO:0008022; F:protein C-terminus binding; IPI:UniProtKB; . GO GO:0019901; F:protein kinase binding; IPI:UniProtKB; . GO GO:0008379; F:thioredoxin peroxidase activity; IDA:ParkinsonsUK-UCL; . GO GO:0045454; P:cell redox homeostasis; IEA:InterPro; . GO GO:0034599; P:cellular response to oxidative stress; IDA:ParkinsonsUK-UCL; . GO GO:0034614; P:cellular response to reactive oxygen species; IMP:UniProtKB; . GO GO:0042744; P:hydrogen peroxide catabolic process; IMP:UniProtKB; . GO GO:0001893; P:maternal placenta development; IEA:Ensembl; . GO GO:0007005; P:mitochondrion organization; IMP:UniProtKB; . GO GO:0030099; P:myeloid cell differentiation; ISS:UniProtKB; . GO GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB; . GO GO:0033673; P:negative regulation of kinase activity; IDA:UniProtKB; . GO GO:0018171; P:peptidyl-cysteine oxidation; IDA:ParkinsonsUK-UCL; . GO GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB; . GO GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB; . GO GO:0051881; P:regulation of mitochondrial membrane potential; IMP:UniProtKB; . GO GO:0042542; P:response to hydrogen peroxide; IDA:UniProtKB; . GO GO:0032496; P:response to lipopolysaccharide; ISS:UniProtKB; . GO GO:0006979; P:response to oxidative stress; IMP:UniProtKB; . GO GO:0000302; P:response to reactive oxygen species; TAS:Reactome; . Gene3D 3.40.30.10; -; 1; . InterPro IPR000866; AhpC/TSA; . InterPro IPR019479; Peroxiredoxin_C; . InterPro IPR012336; Thioredoxin-like_fold; . InterPro IPR013766; Thioredoxin_domain; . Pfam PF10417; 1-cysPrx_C; 1; . Pfam PF00578; AhpC-TSA; 1; . SUPFAM SSF52833; SSF52833; 1; . PROSITE PS51352; THIOREDOXIN_2; 1; .

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